Andreas Trumpp is Professor and Head of the Division “Stem Cells and Cancer” and Coordinator of the Research Program “Cell and Tumorbiology” at the German Cancer Research Center (DKFZ).
Managing Director of the “Heidelberg Institute for Stem Cell Technology and Experimental Medicine” (HI-‐STEM gGmbH) Im Neuenheimer Feld 280 69120 Heidelberg, Germany.
The Trumpp team has contributed to a better understanding of the molecular and cellular basis of normal and malignant stem cell self-‐renewal and differentiation and the role of MYC. They demonstrated that the most potent hematopoietic stem cells (HSC) are retained in a dormancy state during homeostasis preserving their genomic integrity. However, bacterial/viral infections or chemotherapy activates dormant HSCs to quickly restore tissue functionality (Cell 2008, 2016; Nature 2009, 2015, Cell Stem Cell 2014). The group has also isolated circulating metastasis stem cells in the blood of breast cancer patients and identified a novel mechanism mediating resistance of pancreatic tumors to clinically used drugs (Nature Biotech. 2013; Nature Medicine 2016).
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